Extracting skin cells from patients with heart failure and transforming them into healthy, beating heart tissue is expected to be used to treat this disease. Creative Bioarray is committed to developing safe and efficient reprogramming strategies to transform skin cells into heart cells, opening up prospects for the development of technologies to repair the damage caused by heart attacks.
Introduction
Heart disease is the leading cause of death in the world, but recent developments in medicine have improved the survival rate of heart attacks. Some studies have reported that a heart attack is always accompanied by injury and death of heart cells, hardening of the heart area, and reduced pumping function. Because the adult heart has a very limited ability to produce new cells, it is necessary to find a method to replace the cells lost after a heart attack, such as transplanting stem cells or adult heart cells into the damaged heart. However, most transplanted adult cells do not survive or integrate correctly into the heart, and few stem cells can be induced to become cardiac cells.
Recent advances in stem cell biology and tissue engineering have allowed researchers to find ways to stimulate new heart cells and repair the injured heart, but a major problem is the lack of a good source of human cardiomyocytes and the problem of immune rejection. As a result, scientists have begun to look at cell reprogramming as a way to regenerate damaged heart muscle. There have been several reports on reprogramming skin cells into heart cells, providing newfound optimism in the search for ways to regenerate muscle lost in a heart attack.
Fig.1 Chemically induced cardiomyocytes (ciCMs) from human fibroblasts (HFFs). (Cao, 2016)
Our Strategies
Creative Bioarray has established several efficient reprogramming strategies including chemical reprogramming as well as chemical binding transcription factor-mediated reprogramming to help clients transform skin cells into heart cells.
- We extracted skin cells from patients with heart failure and reprogrammed them into hiPSCs by adding three TFs and a small molecule called valproic acid to the nucleus, followed by differentiating the resulting hiPSCs into cardiac myocytes.
- We transformed skin cells into cardiac cells by using a combination of chemicals. This is a more efficient and reliable chemical reprogramming method to reprogram cells and avoid the medical problems surrounding genetic engineering.
- We generate beating heart cells from skin cells in an accelerated manner through a combination of the TF and a four-molecule 'cocktail' called SPCF.
Applications
- Development of pharmaceutical-based myocardial regeneration therapies
- Application in improving cardiac pumping
- Drug screening
Advantages
- Professional research team
- Customer-centered service
- Flexible and efficient custom solutions
With a professional cell reprogramming technology platform, Creative Bioarray has formed good partnerships with many customers and helped them successfully reprogram skin cells into heart cells. Our efficient technical support will accelerate your research in related fields. Please contact us directly for more details.
Reference
- Cao, N.; et al. Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science. 2016, 352(6290): 1216-1220.