Stem cell research has been limited by ethical issues. Creative Bioarray has avoided some of the practical and ethical pitfalls of stem cell research by developing new techniques to reprogram somatic cells into embryonic stem cells. The scientific services we provide are helpful for researchers to study the special properties of stem cells.
Background
The primary source of human embryonic stem cells is early embryo banks that are redundant to the needs of women undergoing in vitro fertilization. The development of cell reprogramming technology has expanded the source of embryonic stem cells without the need for embryonic material. It relies on returning ordinary body cells to an earlier stage of development where they regain the potential to be able to give rise to any of the body's multiple different cell types. Scientists have now achieved this goal with the help of advanced reprogramming tools and strategies.
Following the successful transformation of monkey skin cells into embryonic stem cells in 2007, scientists at the Oregon National Primate Research Center (ONPRC) and Oregon Health & Science University have successfully reprogrammed human skin cells into embryonic stem cells. These generated cells were able to transform into several different cell types, including liver cells, nerve cells and heart cells, just like normal embryonic stem cells. In addition, there is no transplantation rejection problem because these reprogrammed cells can be made with nuclear genetic material from the patient. Stem cell therapies hold the promise of replacing cells that have been damaged by injury or disease, as well as treating diseases or conditions including Parkinson's disease, heart disease and spinal cord injuries.
Fig.1 Graphical summary of human embryonic stem cells obtained by somatic cell nuclear transfer. (Tachibana, 2013)
Our Services
Researchers at Creative Bioarray have successfully helped clients reprogram human skin cells to cells with the same unlimited properties as embryonic stem cells. We offer the following services to our clients:
- Reprogramming skin cells into pluripotent embryonic stem cells by an optimized somatic cell nuclear transfer (SCNT) method to generate patient-matched nuclear transfer (NT)-ESCs.
- Reprogramming cells into three major stem cell types that comprise early-stage embryos by implanting a combination of transcription factors into mouse skin cells.
Applications
- Development of safe and effective stem cell treatments
- Provide a valuable method to develop human stem cell lines
- Generation of immunocompatible cells for tissue engineering and transplantation medicine
Advantages
- Does not involve the use of fertilized embryos
- Customer-specific solutions
- Professional technical support
Creative Bioarray has focused on the development in the field of skin cell reprogramming for many years and made great contributions to customers' scientific research by providing industry-leading reprogramming services. If you are interested in our services, please feel free to contact us for consultation.
References
- Tachibana, M.; et al. Human embryonic stem cells derived by somatic cell nuclear transfer. Cell. 2013, 153(6): 1228-1238.
- Benchetrit, H.; et al. Direct induction of the three pre-implantation blastocyst cell types from fibroblasts. Cell Stem Cell. 2019, 24(6): 983-994.