With significant advances in the field of cell reprogramming, iPSC promises to be a very potential tool in neurotoxicity screening. Creative Bioarray is committed to helping clients assess neuronal toxicity by generating iPSC-derived neurons and establishing in vitro models to better explain human neurotoxic responses as well as screen drug candidates. Our specialized solutions will make a significant contribution to your scientific research.
Background
In drug development, toxic effects of drugs can lead to neurotoxicity, which in turn can cause temporary or permanent damage to the peripheral or central nervous system. As with hepatotoxicity and cardiotoxicity evaluation, the development of effective in vitro models and robust screening tools is critical to evaluate the neurotoxicity of drug candidates to accelerate drug development. hESC-derived neuronal cells have been used for neurotoxicity screening, offering the possibility of measuring neuronal network function in vitro over long periods of time. With the recent rapid development of cell reprogramming techniques, hiPSC are expected to be attractive models for neurotoxicity screening.
It has been demonstrated that iPSC-derived neurons exhibit the behavior and function of mature neurons and are available in large numbers. Neurotoxicity testing models based on these cells can be used not only to study the adverse effects of drug candidates on neuronal cells, but also to screen for general neurotoxicity in assays of lead compounds. In summary, iPSC technology provides a new source of human cells for neuronal predictive toxicology and will largely reduce animal experiments as well as the cost of preclinical development.
Fig.1 IPSCs and their potential for toxicity testing and drug screening. (Csöbönyeiová, 2016)
Solutions for Neurotoxicity Assessment based on Cell Reprogramming
In order to assess the neurotoxicity that may occur during drug development, Creative Bioarray is committed to developing reliable and validated screening tools to identify chemical compounds that may affect human nervous system development. We primarily use iPSC-based neurite outgrowth assays to assess neuronal development and neurotoxicity. The solutions we offer include but are not limited to：
- Identification of neurotoxic effects using iPSC-derived neurons.
- Quantification of complex neuronal networks using multi-parametric image analysis.
- Assessing and prioritizing the neurotoxic potential of chemicals.
Advantages
- Fully developed and improved assays
- Systematic analysis platform and detailed analytical reports
- Time-saving and cost-effective
- Detailed after-sales service
To satisfy our customers' scientific needs in drug toxicity assessment, Creative Bioarray has been working hard to develop efficient iPCS-based high-throughput screening tools to assess the neurotoxicity of large compound libraries. Our advanced technology and professional solutions will save your time and cost and fast-track your projects to completion. If you need neurotoxicity assessment services, please contact us and we will respond promptly.
Reference
- Csöbönyeiová, M.; et al. Toxicity testing and drug screening using iPSC-derived hepatocytes, cardiomyocytes, and neural cells. Canadian journal of physiology and pharmacology. 2016, 94(7): 687-694.