Human iPSCs provide a valuable model system for studying the genetic basis of human heart disease. Based on a state-of-the-art cell reprogramming platform, Creative Bioarray is committed to using iPSCs to model cardiovascular traits and diseases and to develop strategies for the use of iPSC for biomedical applications. Our professional and rational solutions will accelerate your scientific research.
iPSC for Modeling Heart Disease
Cardiovascular diseases are the leading cause of death worldwide, including rheumatic heart disease, coronary heart disease, and congenital heart disease. Much of the current understanding of the molecular mechanisms of human cardiovascular disease comes from genetic animal models and heterologous expression systems. However, the genomes differences and considerable functional species differences in hearts between human and non-human have limited in-depth studies of the molecular basis of many heart diseases. Therefore, there is an urgent need for in vitro cardiac disease models that can accurately reflect human disease phenotypes. iPSC technology is rapidly advancing to make it possible to generate human or even patient-specific disease cell models.
iPSC represents a novel approach that makes it possible to generate human cells that match the patient of interest and that recapitulate the hallmark features of heart disease in a culture dish. hiPSCs can expand into very large numbers and differentiate into various cell types associated with cardiovascular diseases including vascular endothelial cells, cardiomyocytes and smooth muscle cells, allowing researchers to dissect the molecular basis of disease processes within and outside the cardiovascular system.
Fig.1 iPSCs for cardiovascular disease modeling and precision medicine studies. (Musunuru, 2018)
Our Solutions
To help our clients build iPSC-based models of cardiovascular disease, our researchers offer the following solutions:
- Selecting appropriate disease targets.
- Guiding hiPSC differentiation into phenotypically relevant cell populations.
- Identifying disease-related phenotypes.
Our Technical Support
- Generation of hiPSC derivatives for the research of cardiovascular disease, including pluripotent cardiovascular progenitors and their differentiated derivatives, as well as lineage-specific vascular smooth muscle and endothelial cells.
- Establishment of patient-specific hiPSC models of cardiovascular diseases.
Applications
- Research on pharmacogenomics and drug development
- Discovery of mechanism-specific therapeutics
- Early diagnosis of heart disease
- Evaluation of efficacy and safety in a human context before drug candidates reach patients
Advantages
- Highly trained technicians
- Advanced technology platforms
- Professional and reliable solutions
- High-quality services and cost-effectiveness
Creative Bioarray combines new technologies in the fields of human genetics, gene targeting manipulation and tissue engineering to provide scientific solutions for our clients to build iPSC-based heart disease models. Our innovative technologies and expert experimental guidance will accelerate your research progress in the field of cardiovascular medicine. Please contact us directly if you are interested in our solutions.
Reference
- Musunuru, K.; et al. Induced pluripotent stem cells for cardiovascular disease modeling and precision medicine: a scientific statement from the American heart association. Circulation: Genomic and Precision Medicine. 2018, 11(1): e000043.