The creation of patient-derived iPSCs has enabled the in vitro modeling of complex diseases. Combining advanced genome editing technologies with a best-in-class cell reprogramming platform, Creative Bioarray is committed to helping customers create cancer patient-derived iPSC disease models to research a variety of cancer types. We look forward to the opportunity to provide you with high-quality services and optimal solutions.
iPSC for Modeling Cancer
Cancer is a disease that is strongly associated with genetics and environmental factors and is one of the leading causes of death after cardiovascular disease in developed countries. Since cancer is a multi-gene and multi-step disease that develops, understanding the genetic mechanisms that alter the disease from onset to progression is critical to developing efficient therapeutic approaches. Although the development of cancer mouse models, as well as human cancer cell models based on immortalized cancer cell lines, has led to some insightful information in the study of cancer, the inability to mimic tumorigenesis and early progression has limited the study of mechanisms of tumor development.
The development of new models based on disease-relevant human cells to identify the right biomarkers that can be used for treatment is a major challenge in cancer research. Current technological developments in iPSC reprogramming and recent advances in genome editing, tissue engineering, and xenograft models offer new opportunities to study cancer in a patient-specific context. Modeling cancer pathogenesis and progression using iPSCs can overcome the shortcomings of previous techniques and provide us with important new insights into tumorigenesis and progression.
Fig.1 Somatic cell nuclear transfer (SCNT) leads to reprogramming of the cancer cell nucleus. (Navarro, 2018)
Our Solutions
Cancer modeling has become a rapidly transformable and promising application in the field of iPSCs. Researchers at Creative Bioarray focused on building hiPSC derived cells and organoids to help customers accelerate cancer research. In addition, we provide customers with solutions for applying hiPSC-based cancer modeling to biomarker and therapeutic target identification and drug discovery.
- Reprogramming of cancer cell lines. We have successfully reprogrammed multiple human cancer cell types into iPSCs, such as gastrointestinal cancers, hepatocellular carcinoma, pancreatic cancer, and small cell lung cancers. The cancer iPSC lines we have established can be used to follow different stages of cancer progression.
- iPSC-derived organoid. The techniques we have developed to construct 3D spheroids and organoids have enabled the creation of physiologically relevant cancer models and promoted cancer drug discovery.
- Mapping the cells of cancer origin by directed differentiation of iPSCs.
- Disease propagation modeling to dissect the genetic basis of cancer development.
- Modeling the tumor microenvironment for evaluating invasiveness and metastatic capacity using iPSC-derived organoids.
Applications
- Drug discovery
- Identification of potential biomarkers
- Study on the molecular mechanism
Advantages
- Comprehensive disease modeling services
- Innovative research teams
- High-quality services and cost-effectiveness
Over the years, Creative Bioarray has worked to generate iPSCs with well-defined genetic backgrounds to mimic cancer progression and to help clients explore the mechanisms of cancer development. If you need professional solutions for this, please contact us and we look forward to contributing to your research.
Reference
- Navarro, A.M.; et al. Modeling cancer using patient-derived induced pluripotent stem cells to understand development of childhood malignancies. Cell death discovery. 2018, 4(1): 1-9.